Leucovorin is also used in combination with the chemotherapy 5-fluorouracil in treating colon cancer. In this case, folinic acid is not used for "rescue" purposes. Rather, folinic acid enhances the effect of 5-fluorouracil on inhibiting thymidylate synthase.

Leucovorin is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine.

 

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Dosage and using this medicine

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