Please inform your doctor if you are taking any of the following medicines: phenytoin (Dilantin®, Phenytek®), fosphenytoin (Cerebyx®), ethotoin (Peganone®); phenobarbital (Luminal®); or primidone (Mysoline®). You may require a dosage adjustment or special monitoring during treatment.

Moreover, do not use leucovorin without first talking to your doctor if you have: anemia caused by vitamin B12 deficiency; a history of seizures or central nervous system (CNS) problems (e.g., CNS metastases) that may increase the risk of seizures; mouth sores (stomatitis or mucositis); or vomiting or diarrhea. You may not be able to take leucovorin, or you may require a dosage adjustment or special monitoring during treatment if you suffer from any of the above symptoms.

Leucovorin is in the FDA pregnancy category C. This means that it is not known whether leucovorin will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Additionally, it is not known whether leucovorin passes into breast milk. Do not take leucovorin without first talking to your doctor if you are breast-feeding a baby.

 

FDA Information

Why is this medication prescribed?

Other uses for this medicine

Dosage and using this medicine

What should I do if I forget a dose?

What side effects can this medication cause?

What storage conditions are needed for this medicine?

In case of an emergency/overdose